(2013). (2004). Jian-Pi-Yi-Shen improved the hematological parameters and stimulated EPO production (Chen et al., 2019). 103, 454–460. Structures and immunological activities of two pectic polysaccharides from the fruits of Ziziphus jujuba Mill. Fall color is often a showy yellow, but not consistent. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Articles, University of Studies G. d'Annunzio Chieti and Pescara, Italy, Zhengzhou University of Light Industry, China. The pre-incubation of jujube extract (30, 100, and 300 mg/ml) for 5 min at 37°C in platelet-rich plasma was reported to suppress collagen (2 mg/ml)-, thrombin (0.4 U/ml)-, and arachidonic acid (100 mM)-induced aggregation of platelets (Seo et al., 2013). Exp Ther Med 5, 1755–1759. Effect of Fructus Jujubae polysaccharide on the hematopoietic function in mice model of both qi and blood deficiencies. In Huangdi Neijing (475–221 BC), a classic medical text from ancient China, jujube was recorded as one of extremely valuable fruits. Med. Front. The intake of jujube is believed to increase blood supply to the spleen meridian that further improves nutrient uptake and strengthens the immune system. In China, jujube has been made into a wide range of products, i.e., juice, vinegar and wine. Food Chem. Although the common names are red date and Korean date, the scientific classification of jujube is Ziziphus jujuba. These results support the effect of jujube on HIF-1α expression in both mRNA and protein levels. Food Chem. 61, 2709–2719. The effect of jujube extract on anti-complementary activity was also reported. Results suggest that ZFE (250, 500, 1000 μg/ml) and BA (10, 20, 40 μg/ml) were able to inhibit the DNA damaging effect caused by MMS and H2O2 indicative of their protection against the genotoxin. doi:10.1016/j.ijbiomac.2011.04.006 | PubMed Abstract, Li, S. P., Zhao, K. J., Ji, Z. N., Song, Z. H., Dong, T. T., and Lo, C. K. (2003). 26, 42–46. Spinosa. doi:10.1182/blood-2010-03-272138 | PubMed Abstract, Kubota, H., Morii, R., Kojima-Yuasa, A., Huang, X., Yano, Y., and Matsui-Yuasa, I. The intake of jujube extracts at concentrations of 150 and 250 mg/kg/day significantly stimulated thymus and spleen indices in mice, which indicated obviously strengthening the non-specific immunity in jujube-treated mice (Li et al., 2011). Role Of Ziziphus Jujuba In Ancient Medicine selections. According to Shennong Bencao Jing written between 300 BC and 200 AD, one of the earliest books specializing in Chinese medicine, jujube was regarded as one of the top-grade medicinal herbs that could extend one’s life expectancy by nourishing blood, increasing sleep quality and improving digestive system. Int. On the other hand, the intake of Jian-Pi-Yi-Shen, a Chinese herbal decoction comprising of Astragali Radix, Atractylodis Macrocephalae Rhizoma, Dioscoreae Rhizoma, Cistanches Herba, and other four herbs, was able to improve renal function and kidney injury in anemia rats suffering from chronic kidney disease (Chen et al., 2019). 2016;50:144–158. J. Chin. Over 400 cultivars have been selected. J. Biol. Free iron is released to blood circulation by ferroportin and further carried to bone marrow (Kovtunovych et al., 2010). It is hardy to zone (UK) 6. 2016 Jun;22 Suppl 2:24-31. Based Complement. Planta Med. 62, 1890–1897. Jian-Pi-Yi-Shen decoction relieves renal anemia in 5/6 nephrectomized rats: production of erythropoietin via hypoxia inducible factor signaling. Compared with model group, the pre-treatment with jujube extract at different doses (100, 200, and 400 mg/kg/day) in colon of rats for 5 days by oral gavage significantly induced mRNA expressions of Nrf2 and HO-1, giving the highest response by seven and two folds, respectively (Almeer et al., 2018). (2016). (2015). J. Chromatogr. The immune response is impaired in anemia condition. (2019). Furthermore, the authors described that jujube at various concentrations (30–200 μg/ml) showed a significant dose-dependent promotion of splenocyte proliferation, with the highest response at ∼100% increase. 277, 238–245. In support of this notion, the water-soluble polysaccharide isolated from jujube stimulated proliferation of lymphocyte. 149, 1008–1018. Thus, the function of jujube in promoting EPO expression in renal anemia patients was in line to that of Jian-Pi-Yi-Shen (Chen et al., 2019). doi:10.1021/jf200371r, Du, C. Y., Choi, R. C., Zheng, K. Y., Dong, T. T., Lau, D. T., and Tsim, K. W. K. (2013). FIGURE 1. 260, 28–36. 322, 836–842. doi: 10.1515/jcim-2016-0009. doi:10.1016/j.phymed.2011.09.071 | PubMed Abstract, Zhao, Z., Li, J., Wu, X., Dai, H., Gao, X., Liu, M., et al. Schuster, S. J., Badiavas, E. V., Costa-Giomi, P., Weinmann, R., Erslev, A. J., and Caro, J. Pharmacol. Zizyphus jujuba protects against ibuprofen-induced nephrotoxicity in rats. The content of benefit ingredients within jujube could be changed robustly between fresh jujubes and dried ones (Guo et al., 2015; USDA, 2012; Chen et al., 2013). Helmy I.M.F., Wafaa M., Abozied N. Nutritional evaluation of some products from ber fruits. 21, 320–324. Nutr. Compared with model mice, the decreased levels of RBC, hemoglobin and hematocrit were reversed by treatment with jujube extract; while the increased level of platelet however was down regulated in jujube-treated mice (Xu et al., 2004). (2016) investigated the inductive roles of GZT on EPO expression in cultures. Food Chem. In addition, Xu et al. In addition, jujube was reported to contain numerous minerals, e.g., iron and vitamin. The circulating EPO is produced by adult kidney cells; while kidney dysfunction contributes to inadequate amount of EPO production and renal anemia. (2011). In this study, mice were injected with azoxymethane followed by three cycles of dextran sulfate sodium, as to induce colitis-associated colon, before the intake of jujube extract for 70 days. The name Ziziphus is related to an Arabic word and ancient Greeks used the word ziziphon for the jujube. Mutagen. Hematol. Formul. In human endothelial cells treated with betulinic acid, the endothelial nitric oxide synthase expression and nitric oxide production were robustly increased (Steinkamp-Fenske et al., 2007). Hence, possible signaling pathways involved in jujube polysaccharide-treated in vitro or in vivo models are needed for further investigation. Metab. Thirugnanasampandan R, Ramya G, Bhuvaneswari G, Aravindh S, Vaishnavi S, Gogulramnath M. J Complement Integr Med. Cultured Hep3B cells were treated with GZT extracts (0.5–4.0 mg/ml) for 24 h. Applied GZT was able to stimulate the mRNA and protein expressions of EPO. Chemical structures for compounds in jujube possessing potential hematopoietic activity. Besides, the triterpene acid fraction of jujube at a dose higher than 10 μg/ml was able to inhibit the production TNF-α (Yu et al., 2012). doi:10.1159/000190975 | PubMed Abstract, Ninave, P. B., and Patil, S. D. (2019). Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK expression in ulcerative colitis in rats via induction of Nrf2 and HO-1 expression. Betulinic acid, found in Zizyphi Spinosi Semen and jujube, possessed combined properties of inducing endothelial nitric oxide synthase and decreasing nicotinamide adenine dinucleotide phosphate oxidase. 11:593655. doi: 10.3389/fphar.2020.593655. In the lipopolysaccharide (LPS)-induced macrophages, the pre-treatment with jujube water extract repressed the expressions of IL-1β and IL-6 (Chen et al., 2014a). doi:10.1021/jf104018u | PubMed Abstract, Zhu, R., Fan, Z., Dong, Y., Liu, M., Wang, L., and Pan, H. (2018). doi:10.1016/j.fct.2009.11.045 | PubMed Abstract, Almeer, R. S., Mahmoud, S. M., Amin, H. K., and Abdel, M. A. Environ. von Adeela Amjad, Qasim Raza, et al. Biosci. Structure analysis of a heteropolysaccharide from Taraxacum mongolicum Hand.-Mazz. Taschenbuch 48,82 € 48,82 € KOSTENLOSE Lieferung. 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